Timeline of Alzheimer's Disease- History of Alzheimer's Disease - Kalamazoo Center for Medical Studies - Grant provided by the National Institutes of Health

History of Alzheimer's Disease

Kalamazoo Center for Medical Studies

MSU/KCMS History of Diseases Series:

Alzheimer's Disease (AD) Timeline

1864	Dr. Alois Alzheimer born in Bavaria
1901-1906	Dr. Alzheimer observes 51 year old female, Auguste D., of Frankfurt, Germany
1906	Dr. Alzheimer published histological changes associated with AD
1910	Emil Kraepelin names “Alzheimer’s Disease”
1910-1960s	AD remains little known disease
1974-1975	Establishment of the National Institute of Health/ National Institute on Aging
1976	Biochemical changes in brain associated with AD
1979	Alzheimer’s Association founded
1980s	Research-Clinical trials
	AD Becomes Social Movement
	Research on biochemistry of toxic proteins of plaques and tangles
1987	Rita Hayworth dies of AD
1993	Cognex is first FDA approved drug to treat AD
1994	Possible effect of estrogen on AD is postulated
1996	Aricept FDA approved
1997	Effect of antioxidants on AD studied
1999	Genetic mutations linked to programmed cell death of neurons
	Development of techniques leading towards direct genetic manipulation for treatment of AD
	First anti-AD vaccine tested
2000	Exelon FDA approved to treat AD
	Brain imaging used to study AD
2001	Razadyne (previously Reminyl®) FDA approved
2002	Clinical trial of anti-Alzheimer’s disease vaccine conducted
2003	Namenda FDA approved
2004	President Reagan dies of AD
	Diabetes linked with increased risk of Alzheimer’s